Duane B. Huggett **Ph.D. Assistantships

Available Fall 2008

Assistant Professor

Department of Biology

Institute of Applied Sciences

University of North Texas

P.O. Box 310559

Denton, TX 76203

(T) 940-891-6956

(F) 940-565-4297

dbhuggett@unt.edu

Education

Ph.D. Pharmacology and Toxicology, 2001, University of Mississippi

M.S. Biological Sciences, 1998, University of Mississippi

B.S. Biological Sciences, 1996, Virginia Polytechnic and State University

Research Interests

My research interests are in four broad areas: 1) Environmental toxicology, chemistry and risk assessment of chemical and biological stressors; 2) Bioconcentration and bioaccumulation of contaminants; 3) Internal dosimetry and, 4) Eco-pharmacology and physiology.

Experience

· 2006-Present, Assistant Professor, University of North Texas

· 2003-2006, Principal Scientist, Pfizer Global Research and Development

· 2001-2003, Research Scientist, Pfizer Global Research and Development

Current Funding

· Cardiovascular parameters in fish influencing bioconcentration and bioaccumulation. (2007-2008). International Life Sciences Institute-Human and Environmental Sciences Institute (ILSI-HESI) (Principal Investigator)

· Bioconcentration and Early Life Stage Toxicity of Selected Pharmaceuticals in Fish (2007-2009). Pfizer Global Research and Development (Principal Investigator)

· Interaction of Nicotine and Menthol in Mice (2008). (Principal Investigator)

· In vitro and In vivo metabolism of clofibric acid. (2007-2008) Pfizer Global Research and Development (Principal Investigator)

· In Vivo metabolism of propranolol (2007-2008) Pfizer Global Research and Development and AstraZeneca Brixham (Principal Investigator)

Laboratory Group

Jean Storey (Masters)

Santos Garcia (Masters)

Allison Allen (Masters)

Cristi Gomez (Ph.D.)

Lene Peterson (Post-Doc)

Jamie Stine (Undergraduate-McNair Scholar)

Wendy Pace (Undergraduate)

Jacob Mum (Undergraduate)

Monica Tamil (TAMS-undergraduate)

Ramya Raghavan (TAMS-undergraduate)

Adriana Rathjen (TAMS-undergraduate)

Selected Publications

G.T. Ankley, B.W. Brooks, D.B. Huggett, J.P. Sumpter. (2007). Repeating History: Pharmaceuticals in the Environment. Environmental Science and Technology (In Press).

S.W.Kennedy, S.Euling, D.B.Huggett, W.De Coen, J.Snape, T.Zacharewski, J.Kanno. (2007). The Development of Genomic-Based Screening Assays for Ecotoxicology. In. G.Ankley (ed) SETAC Pellston Workshop: The Role of Ecotoxicogenomics in Ecological Risk Assessment. (In Press).

J.L. Flippin, D.B. Huggett, C.M. Foran. (2007). Changes in the timing of reproduction following chronic exposure to ibuprofen in Japanese medaka. Aquatic Toxicology 83:73-78.

D.B. Huggett, W.H. Benson, K. Chipman, J.C. Cook, L.E. Gray, L.B. Kinter, R.D. Meyerhoff, V. Trudeau. (2005). The Role of Mammalian Data in Determining Pharmaceutical Responses in Aquatic Organisms. In R.T. Williams (ed) SETAC Pellston Workshop: Pharmaceuticals in the Environment.

T.H. Hutchinson, S. Barrett, M. Busby, D. Constable, A. Hartman, E. Hayes, D. Huggett, R. Lange, A.D. Lillicrap, J.O. Straub, R.S. Thompson. (2003) Proposed Reduction in Fish Acute Ecotoxicity Testing for Environmental Assessments of Pharmaceuticals. Environmental Toxicology and Chemistry 22:3031-3016.

D.B. Huggett, J.C. Cook, J.E. Ericson, R.T. Williams. (2003) Theoretical Model For Prioritizing Potential Impacts of Human Pharmaceuticals To Fish. Journal of Human and Ecological Risk Assessment. 9:1789-1799.

D.B. Huggett, C.M. Foran, B.W. Brooks, J. Weston, B.N. Peterson, E. Marsh, D.Schlenk. (2003). In Vitro and In Vivo Comparison of Municipal Effluent Estrogenicity. Toxicological Sciences. 72:77-83.

D.B. Huggett, I. Khan, J.C. Allgood, C.M. Foran, D. Schlenk. (2003) Determination of Beta-Adrenergic Receptor Blocking Pharmaceuticals in United States Wastewater Effluent. Environmental Pollution. 121:199-205.

D.B. Huggett, B.W. Brooks, B. Peterson, C.M. Foran, D. Schlenk. (2002) Toxicity of Select Beta-Adrenergic Receptor Blocking Pharmaceuticals (B-Blockers) to Aquatic Organisms. Archives of Environmental Contamination and Toxicology. 43:229-235.

D.B. Huggett, D.Schlenk, B.R. Griffin. (2001) Toxicity of Copper in an Oxic Stream Sediment Receiving Aquaculture Effluent. Chemosphere 44: 361-367

D.B. Huggett, W.B. Gillespie, Jr.,and J.H. Rodgers, Jr. (1999) Copper Bioavailability in Steilacoom Lake Sediments. Archives of Environmental Contamination and Toxicology. 36:120-123.